Year : 2022 | Volume : 6 | Issue : 2 | Page : 66-
Physiotherapy in musculoskeletal Conditions: AB No: 27: Relationship between clinical variables and high sensitive C reactive protei in stratified groups of low back pain
P. Antony Leo Aseer
Sri Ramachandra Institute of Higher Education and Research
Purpose: The broad aim is to analyze the relationship between clinical variables and high-sensitive C reactive protein (hs-CRP) in stratified groups of low back pain. Relevance: The study was to evaluate the magnitude of effect between the biomarkers of inflammation and clinical variables in stratified groups of nonspecific low back pain. Participants: 50 subjects (aged between 30–45 years) with the diagnosis of non-specific low back pain using convenient sampling were included. Participants with history of diabetes and cardiovascular diseases were excluded. Methods: Correlational study design. All subjects were screened and stratified using STarT back screening tool. Clinical variables of pain severity, functional disability using Oswestry Disability Index-Tamil (ODI-T) and blood samples for analyzing the levels of hs-CRP were collected. Analysis: Pearson correlation coefficient was used to analyze the relationship between clinical variables and hs-CRP in low, medium and high risk groups. Results: High risk group (mean-12.17 mg/L) exhibited greater serum hs-CRP levels than other groups.There exist a significant positive moderate correlation (r = 0.55, p < 0.007) between pain severity and hs-CRP levels in high risk group. Moreover, moderate positive correlation was also observed between functional disability and hs-CRP levels in all risk categories. Conclusion: There is a six fold increase in serum hs-CRP levels in high risk group predicting poor outcomes. There exist a positive relationship among hs-CRP, functional disability and pain severity in high risk group in nonspecific low back pain. Prospective longitudinal studies can be carried out to further establish the study findings. Implications: High sensitive C - reactive protein served as a novel tool in detecting the presence of inflammatory mediators and further drives for more individualised treatment approach. Establishing treatment strategies (biopsychosocial approach) in high risk group using biomarkers is of paramount importance.